Over 200 Common Drugs Linked to Depression

Via Newsweek

a woman taking a selfie: Mental illness can affect everything from your immune system to your heart health.

One-third of adults in the U.S. may be unwittingly using prescription drugs that could cause depression or raise the risk of suicide, a study has found.

A team of scientists at the University of Illinois at Chicago warned that over 200 commonly prescribed drugs carry warnings that depression or suicide are potential side effects.

But patients and clinicians may be unaware of this link because the drugs may treat conditions unrelated to depression or mental health. Those include some painkillers; blood pressure and heart medication; hormonal birth control pills; proton pump inhibitors; and antacids.

The study published in the Journal of the American Medical Association is thought to be the first to reveal that polypharmacy—where several drugs are taken at once—is associated with a heightened risk of depressive symptoms.

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Around 15 percent of participants who took three or more of the drugs identified in the study reported experiencing depressive symptoms while using them. In contrast, 5 percent of those who did not use the drugs and 7 percent of those taking one medication said they experienced depression. A further 9 percent of those who took two of the drugs felt depressed. The team found similar patterns in medications that listed suicide as a potential side effect.

To compile their study, the researchers assessed data from the National Health and Nutrition Examination Survey, which documented the prescribed drug use of over 26,000 adults between 2005 and 2014.

Dr. Dima Qato, assistant professor of pharmacy systems, outcomes and policy in the UIC College of Pharmacy, and author of the study said in a statement: “Many may be surprised to learn that their medications, despite having nothing to do with mood or anxiety or any other condition normally associated with depression, can increase their risk of experiencing depressive symptoms, and may lead to a depression diagnosis.

“People are not only increasingly using these medicines alone, but are increasingly using them simultaneously, yet very few of these drugs have warning labels, so until we have public or system-level solutions, it is left up to patients and health care professionals to be aware of the risks.”

Professor Andrea Cipriani, associate professor of psychiatry at the University of Oxford, U.K., said the paper is “important” but “not alarming” and highlighted two important caveats.

“First, the risk of depression was higher in people that took more types of medicine and this may be a result of the medicines interacting, but it may also be because people with chronic illnesses take more medicines and are also more likely to have depression. This was an observational study so we cannot tease this apart.

“Second, this study looked at many medications, including antidepressants. For many of the people who self-reported depression this may simply be because the particular antidepressants didn’t work for them, or that they were biased towards expecting feelings of depression. It doesn’t necessarily mean the antidepressants caused the depression.”

Professor David Baldwin, chairman of the Royal College of Psychiatrists’ Psychopharmacology Committee, said: “The findings emphasize the need for doctors to ask about all prescription and over-the-counter medicines when patients have depressive symptoms.

“If there is a risk of making those symptoms worse, especially where they are taking several medications, then the patient’s condition might be improved by a change in their prescription. This could avoid unnecessary antidepressant treatment.”

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11 Comments
Wip
Wip
June 13, 2018 3:31 pm

Drug nation.

Gilnut
Gilnut
  Wip
June 14, 2018 11:38 am

That’s part of it Wip, but we’ve also been taught and teach our children to automatically assume that people like Doctors and Lawyers are speaking from a position of authority.

People need to know that the 80/20 rule exists in all aspects of life, and just because someone spent a LOT of time and money to get into a position, that does not mean that they actually know how to apply that knowledge. Most doctors nowadays are just licensed drug dealers. BE YOUR OWN HEALTH ADVOCATE, and take responsibility for yourself! That’s the only fix to this problem. The 1% or so that use hardcore illegal drugs aren’t the problem.

IndenturedServant
IndenturedServant
June 13, 2018 4:21 pm
TampaRed
TampaRed
  IndenturedServant
June 13, 2018 10:07 pm

indecent,where you been,haven’t seen you post for awhile–

IndenturedServant
IndenturedServant
  TampaRed
June 14, 2018 12:18 am

Had to bury my parents then spent time at the Fortress of Asshole-itude in the Sawtooths. Had to come back to reality for an appointment and to grab some more tools and run a combine harvester over the lawn. Shit was damn near a foot tall! I’ll be returning to the FoA for the rest of the month tomorrow.

IndenturedServant
IndenturedServant
  IndenturedServant
June 14, 2018 12:24 am

Meant to add that the weather in the pacific northwest has been fucking magnificent! Still no hint of chemtrails that I’ve seen in WA, OR or ID all year. The contrails I’ve seen on passing aircraft look like those of my youth.

Jay M
Jay M
June 13, 2018 4:40 pm

If there is a risk of making those symptoms worse, especially where they are taking several medications, then the patient’s condition might be improved by a change in their prescription.

SO…….. the answer to polypharmacy is to just prescribe another medication.

Silly me- I would just consider stopping some.

MrLiberty
MrLiberty
June 13, 2018 11:10 pm

And yet illegal drugs like psilocybin have shown phenomenal success in treating depression, alcoholism, and other mental conditions. But the natural substances lobby isn’t quite as big as the pharmaceutical lobby or the AMA. So no shock.

Zulu Foxtrot Golf
Zulu Foxtrot Golf
June 14, 2018 12:52 am

Fentanyl? Yeah right. I am more worried about SSRIs and the narcissist generation.

Martin brundlefly
Martin brundlefly
June 14, 2018 9:44 am

I could not find a list of the over 200 medications. Just the short list mentioned here. Anti acids and ibuprofen? Really? I used to take ibu 3 times a day, along with rolaids or ranitadine because the ibu tore up my stomach.

I would like to see the complete list.

KeyserSusie
KeyserSusie
June 14, 2018 10:37 am

Better Living Though Chemistry was a catch phrase popular back in the 60’s. In the early 70’s I began going to dental exhibitions with drug reps present. Valium was fairly new. Ibuprofen was hawked as a new anti-inflammatory . I still recall the ibuprofen rep who visited the dental school and set up an info booth. She would become the mother of my white witch gf and muse, after marrying an Emory M.D. Like most drug and product reps, she was the kind of woman who was hard to say no to. She was way out of my league but I overcame my shyness to chat her up. I suggested to her to talk to a physician I knew from the hospital sleeping quarters for staff where I would shower and sleep. Her daughter confides the description fits her mother nicely. I confess to being an easy mark. And have succumbed to many many along the way, usually for my betterment, adding armaments to my arsenal to combat pathology. Good drug reps are highly sought after. One male rep took me to lunch solely for asking me for names of people who would be good candidates. He hired and trained my suggestion of a very personable female patient.

Back in ’02 or so I told my cut out they should market a drug for depression that is essentially harmless, but with some kind of clinical research to indicate efficacy and charge enormous prices to bulk up the placebo effect for the susceptible. Let patients think it should give them the ability to function better – I even suggested a name for it. Abilify. In 2006 when being treated for PTSD and for self medicating depression with sex and relationships, the psychiatrist at the Professional Enhancement Program prescribed it for me. The first Rx was a freebie. The refill was $400 or so. (now $1000 or so for a month’s supply) I took it for a month and found no difference in my affective mood and discontinued the med.

As my illness/depression was severely effecting me, I was willing to try anything. I eventually tried a SSRI for a while. I could not tell it made a difference. I was enrolled in Florida’s program for wayward health care providers from 2006-2008. They are VERY anti drug yet a mandated psychiatrist not versed in recovery issues wanted to put me on Klonopin – a mack daddy of benzo’s. I passed on the prescription pill solution in favor of cognitive therapy in the rooms of AA. The spiritual healing process was greatly aided by the non denominational promotion of a higher power, one I call by the name of gÖd. I add that the Florida’s Professional Resource Network (PRN) is (was?) a den of dysfunction run by ex sociopaths and though rife with strife, at least is an honest effort for remedy and forced remission.

Newly shingled health care providers take cues from the industry on how to deliver the latest greatest meds. And patients/clients clamor for a pill! Heck, they demand a pill sometimes.
“Take a chill pill” entered the lexicon. Can’t Sleep? Here’s a pill for it. If you are a celebrity or very rich, prescribers and boot leggers will line up to give you magic medicine to give you a leg up on the competition; this a road to going broke, belly up or busted for most people. I can only imagine the pharmaceuticals pushed to Tiger. Performance enhancers and solutions for pain, sleep or dysthymia.

Penicillin was marketed first around 1942. It is slightly older than I am. No one would declare it a bane to civilization. The ethos of the good pill is hard to kill. For every legitimate use of pharmed panaceas, abuses abound. And it is difficult to distinguish between the good, the bad and the just plain ugly effects foisted upon us. The road to hell is paved with good intentions and the path of excess leads to wisdom, wishing for a return from Dante’s infernal warning – “the “realm … of those who have rejected spiritual values by yielding to bestial appetites or violence, or by perverting their human intellect to fraud or malice against their fellowmen”.[1”

God, Save The Queen’s Subjects! is a plea and prayer.