Age-stratified Infection Fatality Rate of COVID-19 Pre-Vaccination

Submitted by aka.attrition

Source: https://www.medrxiv.org/content/10.1101/2022.10.11.22280963v1

ABSTRACT

The infection fatality rate (IFR) of COVID-19 among non-elderly people in the absence of vaccination or prior infection is important to estimate accurately, since 94% of the global population is younger than 70 years and 86% is younger than 60 years. In systematic searches in SeroTracker and PubMed (protocol: https://osf.io/xvupr), we identified 40 eligible national seroprevalence studies covering 38 countries with pre-vaccination seroprevalence data. For 29 countries (24 high-income, 5 others), publicly available age-stratified COVID-19 death data and age-stratified seroprevalence information were available and were included in the primary analysis.

The IFRs had a median of 0.035% (interquartile range (IQR) 0.013 – 0.056%) for the 0-59 years old population, and 0.095% (IQR 0.036 – 0.125%,) for the 0-69 years old. The median IFR was 0.0003% at 0-19 years, 0.003% at 20-29 years, 0.011% at 30-39 years, 0.035% at 40-49 years, 0.129% at 50-59 years, and 0.501% at 60-69 years. Including data from another 9 countries with imputed age distribution of COVID-19 deaths yielded median IFR of 0.025-0.032% for 0-59 years and 0.063-0.082% for 0-69 years. Meta-regression analyses also suggested global IFR of 0.03% and 0.07%, respectively in these age groups.

The current analysis suggests a much lower pre-vaccination IFR in non-elderly populations than previously suggested. Large differences did exist between countries and may reflect differences in comorbidities and other factors. These estimates provide a baseline from which to fathom further IFR declines with the widespread use of vaccination, prior infections, and evolution of new variants.

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5 Comments
The Central Scrutinizer
The Central Scrutinizer
October 25, 2022 12:24 pm

Thank you!

It’s as I’ve said from the beginning…professional shit stirrers scaring the crap out of humanity for fun and profit. Consequences be damned.

Llpoh
Llpoh
October 25, 2022 8:41 pm

The other day there was an article that discussed the Ruby Princess. Of course, the author of that article played funny buggers with the data. Incorrectly pointed out based on the Ruby Princess deaths/ages that an IFR of somewhere around 4% could be extrapolated for the more elderly. Of course, some readers of TBP howled me down and said I was incorrect.

I was of course correct. And John Ionnidis and his crew have established I was in fact correct. Look at the graph. The IFR for those 70 and above range from 3 to 4.5%.

The Ruby Princess data should have been immediately used world-wide to establish risk factors and set policy. It was clear from the beginning that the only cohort at serious risk were the elderly. Yet time and again nothing was done to protect them, while at the same those not at risk were crushed in lock downs. The Ruby Princess was a perfect, large-scale testing ground forthe virus, but the data and significance was ignored.

Children were sacrificed on the alter of the world-wide stupidity. In the two years of “Covid”, children fell almost a year behind in school results. That is an abomination that will take a very long time to overcome, no those children will be disadvantaged throughout their entire lives as a result.

I find it inconceivable that this was not done on purpose. This was known and available to be known by anyone who wished to look. John Ionnidis howled this from the rooftops, but was shunned for his efforts.

I expect none will ever be held accountable.

aka.attrition
aka.attrition
  Llpoh
October 26, 2022 8:29 am

Sad but true, fully agree. TPTB certainly found out how easy it is to control the masses (if they didn’t know already).

Machinist
Machinist
October 25, 2022 8:47 pm

Let’s just cut to the damned chase here. Since my ugly old ass is old, maybe not as old as Stucky, but like who freakin’ who cares, … Elderly Cares, the,uh, interquartile range cutie pies. By gosh she was one little fire cracker, but I die, um, gress or grass,whatever (where’s the prompter?).

Gosh, we had some hellacious grass back in those days. Dave sold some solid shit, what did we call it… Oh hell yeah, Obama gold….. no, Acapold some shit, it was righteous shit. But that afgan shit would , phewwwww, fuk me. Did you know I starred in Weekend at Bernies?

Have you seen that little dark presser? I means, she’s gots that little kink-da-kink look? Ewwww-weee!!!, gonna gets me some dat. Them eyes. Sheeeee-it. She ain’t seen my coconuts yet. The NSA tells me Eppie Island is so available.

Hey, hey, lemme tell ya somthin’. Don’t FUK wid Biden. I’m tellin’ you Councilor.

But, what I want you all to know is that LIFE is good. I’m tellin’ ya’s. Jill, ya know, has always been an easy squeeze, she ‘s so easily intimidated, like my Democratic schlumps. She turns right over and … Hell, I haven’t turned my hand since, I dunno, like since forever!

It’s good to be the the King.

Leobeer
Leobeer
October 26, 2022 9:31 am

I would bet that most of those aged 70+ that died were either very weak and frail or extremely overweight.