Guest Post by Geert Vanden Bossche
The debate and tension over the efficacy of the Covid-19 vaccines are flaring up. Comparative assessments of vaccine-mediated protection from infection, disease, hospitalization, and death in vaccinated and unvaccinated people are all over the place, with results ranging from convincing evidence of benefit to compelling proof of failure depending on the source of information.
Those who’ve become addicted to these comparative statistics seem to forget that gauging the success of human intervention in a pandemic is about measuring success in a dynamic phenomenon and that snapshots taken under certain conditions/settings do not provide information about the overall evolutionary trend and likely health outcome of a pandemic. The latter can only be monitored by measuring temporal changes of parameters that are relevant to public and individual health.
By March 2021, molecular epidemiologists had already expressed their concern about the emergence of a super-variant that ‘might have any combinations of increased transmissibility, altered virulence and/or increased capacity to escape population immunity’ and would, therefore, enjoy a huge fitness advantage1. Back then, their concern was based on phylogenetics-based natural selection analysis indicating that immunity-mediated selective pressure is driving convergent evolution of a diversified spectrum of mutations to ensure viral persistence in the face of mounting infectious and vaccine-induced host immune pressure.
Their findings lead one to conclude that mass vaccination in the presence of more infectious variants inevitably involves selection-driven convergence of compensatory adaptive mutations at positively selected genome sites, and hence promotes enhanced expansion in the prevalence of more transmissible immune escape variants. This would imply that vaccine efficacy is expected to diminish over time while the infection rate would progressively increase. It is reasonable to assume that the evolutionary convergence of more infectious immune escape variants and the culmination thereof into a ‘super -variant’ will also cause distinct trajectories of the pandemic to increasingly converge in countries/regions that are subject to mass vaccination.
An increase in infectious pressure leads to a higher risk of rapid viral re-exposure in the population. As far as previously asymptomatically infected unvaccinated individuals are concerned, rapid re-exposure to SARS-CoV-2 may lead to viral replication on a background of a suboptimal spike (S)-directed immune pressure (due to suboptimal, short-lived anti-S antibodies [Abs] of low affinity) and even to enhanced susceptibility to disease (due to suppression of functional innate Ab capacity by the afore-mentioned suboptimal anti-S Abs). When such suboptimal anti-S immunity occurs in a substantial part of the population it is likely to further increase natural immune selection pressure on viral infectiousness and, therefore, promote further expansion of more infectious variants, thereby giving rise to additional waves of infectious cases and morbidity.
As the evolutionary dynamics of the virus in highly vaccinated countries/regions are now placing huge immune selection pressure on the viral fitness landscape, it is fair to postulate that the highly diversified spectrum of evolutionary trajectories of this pandemic seen in different highly vaccinated countries will now rapidly narrow down to a more uniform path characterized by the following, prognostically unfavorable features:
- Waning of vaccine efficacy as mirrored by a relative increase of morbidity and mortality rates in vaccinees over time
- A relative increase of morbidity and mortality rates over time in vaccinees as compared to the unvaccinated
- A relative increase in suboptimal immunity over time in both the vaccinees and unvaccinated individuals (due to diminished vaccine efficacy and suboptimal naturally elicited Abs, respectively), which may translate into a relative increase in cases of ADE (Ab-dependent enhancement of Covid-19 disease pathology)
- A relative increase in the base-line infectivity rate over time
- Continuing waves of increased infection, morbidity, and mortality rates
- A relative increase in the frequency of more infectious viral variants with immune-resistant phenotypes over time
Conclusion: All experts and public health authorities seem to agree that the evolutionary dynamics of a pandemic are very complex and shaped by an interplay between infectious pressure exerted by the virus on the host immune system and immune pressure exerted by the host on viral infectiousness and that a pandemic can only come to an end when sufficient herd immunity is developed to control the virus. It is, therefore, surprising that none of these authorities seem to worry about the impact that massive immune intervention could have on the evolutionary dynamics of a pandemic that is now characterized by widespread dominance of highly infectious variants.
The impact of any human intervention on these dynamics can only be assessed and measured by monitoring changes in population-level infection, morbidity, and mortality rates, and comparing these rates between vaccinees and unvaccinated individuals as a function of time. Likewise, phylogenetics-based natural selection studies should be conducted on viral sequences to monitor the evolutionary dynamics of SARS-CoV-2 adaptation to public health interventions.
If mass vaccination eventually enables SARS-CoV-2 to evolve dominant immune-escape variants that are capable of escaping from both the adaptive and innate immune systems, the outcome of this pandemic will resemble that of introducing a pathogenic virus into a naive host species. This is actually likely to enhance viral virulence instead of controlling viral disease.
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So the “leaky vaccine” will eventually put all of us at higher risk- vaccinated and unvaccinated, as the biological mutations of the virus trying to adapt and continue to live/reproduce will create more virulent variants. Just great.
It’s not a “virus”, it’s a Bio weapon.
I will add: The “vaccine” is not a “vaccine” it is a Bio Weapon.
Actually it is neither a virus nor a bioweapon. It is a hoax and a psyop. Every single death that has been attributed to “COVID-19” has actually been due to the flu, pneumonia, heart attack, gunshot, or something else, and since the kill shots were rolled out many of the deaths attributed to “COVID-19” have been caused by the kill shots.
SARS-CoV-2 does not exist, and the PCR test that is used to test for it couldn’t detect it even if it did exist. Thus all of the statistics on cases, deaths, vaccine efficacy, etc are meaningless.
This scamdemic has been planned by the NWO for many years to help bring about their one world government and cashless society, and to reduce the world population to 500 million. The kill shots are one of the primary methods they are using to bring about the population reduction. The deaths due to the kill shots are going to increase dramatically over time, after the placebos (which have been used extensively up to now to convince the public that the kill shots are relatively harmless) are replaced with actual kill shots, and after the numerous booster shots have been administered, and after the kill shots have had more time to affect the people who have received them.
piearesquared,
Got proof?
There is ZERO PROOF of this, is all I’m saying.
GOT PROOF? Time is the only thing that can prove this.
You are right that time will prove if I am right, and I am confident that I am right. When people who have been vaccinated start dying by the millions in the coming months and years it will prove that I am right. Of course the government/MSN narrative will be that it was COVID-19, or a new virus, or something else other than the vaccines that killed them. But it will be obvious to anyone capable of critical thinking what is actually killing them.
Make up your mind peiaresquared. It’s either a “hoax and a psyop” and not a bioweapon because all deaths are from natural causes.
Or it IS a bioweapon planned by the NWO for years that is going to be reducing the population after they get around to giving out the “kill shots”.
Of course we are talking about S1 spike protein here. The delivery method is not terribly relevant. It’s either the SARS-COV2 virus (not terribly efficient) or it’s via the jab (much more nefarious). So either the spike protein is a bioweapon or it’s all a fake side show meant to scare us into submission.
SO which is it? A fake psyop to to get control of us, or bioweapon meant to depopulate the world? Your rant says it is both, but logically it can only be one or the other.
I don’t understand what part of my comment is confusing you. The “virus”, a.k.a. SARS-CoV-2, which supposedly causes “COVID-19” is a hoax. SARS-CoV-2 does not exist. However the “vaccines” (i.e., the kill shots) are very real, and they are going to kill many, many people. Some of the kill shots could possibly be considered bioweapons, but it order to be considered a bioweapon the agent that does the killing has to be biological. I don’t know that all of the vaccines will kill by biological methods. Some of them could kill by simple poisons or other non-biological methods. That is why I don’t refer to the vaccines as bioweapons. They are more appropriately called kill shots.
Javelin, how did it turn out for you regarding your exemption request, have been thinking of you and your situation, hoping for the best.
This post is right on the money and should have been written with far fewer words and much plainer language so the average person could cut through the medical gibberish. Any sane person with common sense already knows that the so called pandemic is a genocidal scam created by new world order zealots.
It All Makes Sense Once You Realize They Want to Kill Us
https://www.unz.com/mwhitney/it-all-makes-sense-once-you-realize-they-want-to-kill-us/
I like this wording better.
Holy shit.
I read your link and I pulled up a PDF which they referenced:
The Pfizer mRNA vaccine: pharmacokinetics and toxicity, by Michael Palmer, MD and Sucharit Bhakdi, MD, from July 23rd of this year.
I printed out that paper to have a hard copy on hand. Here’s the abstract:
QUOTE
We summarize the findings of an animal study which Pfizer submitted to the Japanese health authorities in 2020, and which pertained to the distribution and elimination of a model mRNA vaccine. We show that this study clearly presaged grave risks of blood clotting and other adverse effects. The failure to monitor and assess these risks in the subsequent clinical trials, and the grossly negligent review process in conjunction with the emergency use authorizations, have predictably resulted in an unprecedented medical disaster.
End quote.
Here’s a link to the PDF:
https://doctors4covidethics.org/wp-content/uploads/2021/07/Pfizer-pharmacokinetics-and-toxicity.pdf
Thanks.
Makow is full of surprises but most here react to his name with kneejerk reaction. Him and Unz have been feerless in exposing this scami-flu.
Unz postulates it was a bio attack on China/Iran by us.
“During the last eighteen months, I think I’ve stood nearly alone on the Internet in arguing that the late 2019 Covid outbreak that began in Wuhan, China was probably the result of an American biowarfare attack conducted by rogue elements of our own national security establishment.
The individual articles in my long series have been viewed some 350,000 times, but with rather few exceptions almost no one has publicly endorsed such an extremely controversial hypothesis, and almost as few of the multitude of readers have even been willing to acknowledged its existence.”
https://www.unz.com/runz/is-the-tide-finally-turning-on-covid-as-an-american-biowarfare-attack/
big words make head hurt
He is a German physician. This was translated from German to English. Not easy.
Yeah, I can usually understand this author’s writing, but this one is not lucid.
Best translation available: “And unless those days be shortened, no flesh would be saved. But for the sake of the elect those days will be shortened”
What a mouthful.
I take it to mean that Everything is going to be all-right.
The check is in the mail, I love you and get the booster.
Coming to a theater near you soon.
Hopefully Ivermectin et al will continue to be effective.
… assuming you can find a physician not too frightened or intimidated to write you a prescription for it — AND — a pharmacy that will fill that prescription.
Here in the greater Vancouver, WA, area, I had a conversation with a pharmacy tech at one of the local Costco stores … asked him directly if Costco would fill prescription(s) for either IVM or HCQ.
His reply – frightening as it was – is that that would depend on why it was being written.
I asked if that meant that the pharmacist would undertake to override the patient/physician relationship and replace the physician’s judgment as to the best possible treatment for me … and he said, well … yes, it could come to that.
Frightening stuff these days …
“The impact of any human intervention on these dynamics can only be assessed and measured by monitoring changes in population-level infection, morbidity, and mortality rates, and comparing these rates between vaccinees and unvaccinated individuals as a function of time.”
So we have a valid test, to do this with?
My understanding the swab does not work. There is no rona test.
I was told that the swab test identifies the presence of viral particles. It does not determine a specific virus. It is no wonder that the common flu disappeared over the last year. It has been recommended that if you suspect you may have had an illness commensurate with the Chyna flue, you should have an antibody test to confirm .
There is no valid test because there is — nor has there ever been — an isolated and pure sample of what is purported by BigFauci and his fellow conspirators to be the ‘virus’ for this flu strain … nowhere in the world in any medical lab … period.
But, even if it did exist – the existing PCR test was never meant to be used on viruses (per its inventor decades ago to Fauci when TheFauci was trying to use it to ‘diagnose’ hiv/aids) — and especially not when the Ct is being run at 40+ (as the FDA mandates) …
So … you get GIGO … no surprise there.
There are those pundits that claim that — as with ‘climate change’ hysteria — this is meant to be another wealth re-distribution … from the 1st world to the 3d world.
What if that’s at least a part of the plan? What if the 3d world invasion of the 1st world that’s been forced upon the US and the EU for the past 20 or so years is also part of this plan?
When you look at the risks of the jab — and where those risks are — a disturbing picture can emerge: the 1st world is getting the jab en masse — the 1st world is the part of the world that’s at risk for all of the horrors of the jab …
I tried to upload a graphic, not sure how to do so … so here’s what the graphic shows based upon data from 12.27.2020 through 10.19.2021:
Canada: 73% fully jabbed, 78% partly jabbed
UK: 67% and 69%
EU: 64% and 68%
South America: 47% and 65%
US: 56% and 65%
Europe: 54% and 58%
India: 21% and 30% (India, though, has had great success with IVM)
World: 36% and 48%
Indonesia: 23# and 39%
Philippines: 19% and 25%
Africa: 5% and 7.8% (parts of Africa also have utilized IVM and HCQ for their various endemic diseases – so they have some benefit from that …
Are these dots that can be connected – or just … what?
Vanden Bossche has another column out today: https://www.geertvandenbossche.org/post/why-are-the-current-covid-19-mass-vaccinations-to-be-considered-a-public-health-experiment
Key paragraph:
“Mass vaccination programs previously conducted to combat viral epidemics/pandemics (e.g., smallpox, polio, measles, yellow fever) have nothing in common with the ongoing mass vaccination campaigns today as those viruses are very different in terms of their pathogenesis, transmissibility, route of infection, potential reservoirs, predominant effector mechanisms involved in antiviral immunity, susceptibility of population segments, as well as with regard to the vaccines used (all prior vaccination campaigns involved live-attenuated virus). ”
Exactly. Polio and smallpox were 100 TIMES MORE DEADLY. Idiots who compare Covid to smallpox and polio need to be slapped.